In an ever increasing battle for more powerful heart medications, Novartis
One of Novartis' most popular cardiovascular drugs on the market right now is a heart failure drug called Entresto that has made a significant amount of money for the drug maker. This is in contrast to failures that rivals like Amgen
The $9.7 billion purchase price of The Medicines Co. is a sharp premium against the existing market cap of the drug manufacturer. At this time, The Medicines Co. has a market capitalization of $6.7 billion, implying a heavy desire to take advantage of this new pharmaceutical. Inclisiran, an siRNA, reduces the concentration of "bad" LDL cholesterol in the blood, an important pathway to recovery for patients with plaque buildup in their arteries. Profits from the sale of Inclisiran will not go entirely to Novartis, however. They will be split with Alnylam, the pharmaceutical manufacturer that invented the drug.
Inclisiran will compete with other antibodies that prevent the expression of PCSK9, which prevents the liver from clearing LDL cholesterol from the blood. One such example is Amgen